Impact of l-carnitine on contrast induced nephropathy

Impact of L-carnitine on contrast induced nephropathy in patients undergoing elective Percutaneous Coronary Intervention(PCI)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201212178698N5

Enrollment

320

Registered

2013-01-10

Start date

2012-12-30

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic heart disease. Myocardial ischemia followed by decreased oxygen to the myocardium

Interventions

Intervention 1: 3 gram L - carnitine is administrated to intervention patients one day before catheterization (1 g every 8 hours) and lasts for up to 48 hour after it (for three days). Patients urine

Treatment - Drugs

3 gram L - carnitine is administrated to intervention patients one day before catheterization (1 g every 8 hours) and lasts for up to 48 hour after it (for three days). Patients urine sample is colle

Medication will not be given to patients in the control group.Patients urine sample is collected at baseline and 12 hour after catheterization for determination of NGAL. Also serum creatinine and glum

Eligibility

Sex/Gender

Male

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Patients with ischemic heart disease that have more than 50 percent occlusion in angiography findings and candidates for elective Pecrcutaneous Coronary Intevention.Exclusion criteria: cardiogenic shock;ST Elevation Myocardial Infarction;pregnant and lactating womens;patients under 18 years;immunologic or hematologic disorders;current infection;chronic kidney disease;serum creatinine above 2.5 mg/dl;hypothyroidism;epilepsy or convulsion;chronic liver disease;cancer

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
(Neutrophil gelatinase-associated lipocalin (NGAL. Timepoint: baseline and 12 hour after. Method of measurement: Elisa kit.;(Glomerular Filtration Rate (GFR. Timepoint: baseline and 48 hour after. Method of measurement: determination of serum creatinine by chromatography.	—

Secondary

Measure	Time frame
Renal function. Timepoint: 1 month later. Method of measurement: evaluation of patient condition such as death and renal function.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzita Hajhossein Talasaz

Tehran University of Medical Sciences

atalasaz@razi.tums.ac.ir+98 21 6695 4709

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026