ischemic heart disease. Myocardial ischemia followed by decreased oxygen to the myocardium
Conditions
Interventions
Intervention 1: 3 gram L - carnitine is administrated to intervention patients one day before catheterization (1 g every 8 hours) and lasts for up to 24 hour after it (for two days). Patients blood s
Treatment - Drugs
3 gram L - carnitine is administrated to intervention patients one day before catheterization (1 g every 8 hours) and lasts for up to 24 hour after it (for two days). Patients blood sample is collect
Medication will not be given to patients in the control group. Patients blood sample is collected at baseline and 24 hour after catheterization.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Patients with ischemic heart disease that have more than 50 percent occlusion in angiography findings and candidates for elective Pecrcutaneous Coronary Intevention.Exclusion criteria: cardiogenic shock;ST Elevation Myocardial Infarction;pregnant and lactating womens;patients under 18 years;immunologic or hematologic disorders;current infection;chronic kidney disease;serum creatinine above 2.5 mg/dl;hypothyroidism;epilepsy or convulsion;chronic liver disease;cancer
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transforming growth factor beta(TGF-ß). Timepoint: baseline and 24 hour after. Method of measurement: Elisa kit.;CD40L. Timepoint: baseline and 24 hour after. Method of measurement: Elisa kit.;P-Selectin. Timepoint: baseline and 24 hour after. Method of measurement: Elisa kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Major adverse cardiac events)MACE). Timepoint: 1 month later. Method of measurement: evaluation of patient condition such as death, stent thrombosis confirmed by angiography ? acute coronary syndrome defined by AHA ? again revascularization with angioplasty or bypass. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzita Hajhossein Talasaz
Tehran University of Medical Sciences
Outcome results
None listed