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The effect of doxycycline and licorice therapy on gingival cervicular fluid matrix metalloproteinase-8 levels in chronic periodontitis

The effect of adjunctive low-dose doxycycline and licorice therapy on gingival cervicular fluid matrix metalloproteinase-8 levels in chronic periodontitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2012121611771N1
Enrollment
39
Registered
2013-01-10
Start date
2010-10-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention: One 20mg Capsule of Doxycycline per day for six weeks. Intervention 2: Intervention: One 400mg Tablet of Licorice per day for six weeks. Intervention 3: Control: One Plac
Treatment - Drugs
Placebo
Intervention: One 20mg Capsule of Doxycycline per day for six weeks
Intervention: One 400mg Tablet of Licorice per day for six weeks
Control: One Placebo Capsule per day for six weeks

Sponsors

Islamic Azad University Khorasgan Branch (Isfahan)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: chronic mild to moderate periodontitis. Exclusion criteria: Patients with any infectious or systemic diseases; no drug usage at all; pregnant, breast feeder patients; patients allergic to antibiotics; no scaling and root planning or periodontal surgeries in the last six months; no usage of herbal or antibiotic drugs during the last six months; Smokers, alcoholics; patients with poor oral hygiene or patients with poor compliance

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
MMP-8 concentrate in GCF. Timepoint: 0 and 6 weeks. Method of measurement: Nanogram per milliliter by means of ElLISAreader.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShirin Zahra Farhad

Islamic Azad Dental School Khorasgan Branch, (Isfahan), Iran

drsh.farhad@yahoo.com+98 31 1664 1410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026