Effect of photodynamic therapy on inflammatory biomarkers and clinical parameters in moderate to severe chronic periodontitis

Comparative evaluation of the clinical and immunological effects of photodynamic therapy as an adjunctive to scaling and root planing and scaling and root planing alone, in the treatment of moderate to severe chronic periodontitis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012121611770N1

Enrollment

Registered

2013-02-18

Start date

2012-02-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention: Photodynamic therapy and scaling and root planing. Intervention 2: Control : Scaling and root planing alone.

Intervention: Photodynamic therapy and scaling and root planing

Control : Scaling and root planing alone

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Moderate to severe Chronic periodontitis; existence of a minimum of 12 teeth in oral cavity with at least three natural teeth in four sites per quadrant; = 3mm of attachment loss in minimum of 30 percent of teeth; presence of at least one site with pocket depth of = 4mm with bleeding on probing in per quadrant. Exclusion criteria: The ingestion of systemic antibiotics within the last one year, non-surgical periodontal treatment within the last 6 months; smoking; uncontrolled Diabetes; liver disease; malignancy; radiotherapy; pregnancy; females on estrogen therapy; allergic reactions to Toluidine blue.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Probing depth. Timepoint: after 3 month. Method of measurement: Periodontal probe.	—

Secondary

Measure	Time frame
Interleukin-1ß level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;TNF-alpha level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;MMP-9 Level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;MMP-8 Level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.	—

Measure

Time frame

Interleukin-1ß level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;TNF-alpha level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;MMP-9 Level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;MMP-8 Level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.

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Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026