The effect of manual therapy alone and combined with linolenic acid supplementation on carpal tunnel syndrome

Comparative Impact of Manual Therapy Alone and Combined with Linolenic Acid on inflammatory status, oxidative stress, metabolic factors, clinical symptoms and Electromyography in patients with carpal tunnel syndrome: a randomized clinical trial study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20121216011763N63

Enrollment

Registered

2024-04-09

Start date

2024-05-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal tunnel syndrome. Carpal tunnel syndrome

Interventions

Intervention 1: Intervention group: For 14 days, receiving 1000 mg of flax seed oil daily (one capsule per day containing 350 mg of alphalinolenic acid, Barij product) along with manual therapy (Three

Eligibility

Sex/Gender

Male

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Agreement for participation in the study Age of 20 to 65 years old Diagnosing patients with carpal tunnel syndrome by a neurologist: Carpal tunnel syndrome severity: Mild, moderate, or severe.

Exclusion criteria

Exclusion criteria: Not attending follow-up appointments during various phases of the study Reaction and sensitivity to the prescribed supplement Non-compliance with recommendations and nutritional supplements Suffering from cardiovascular diseases, blood pressure, diabetes, liver, kidney, thyroid, malignancies and other neurological disorders smoking Cervical radiculopathy - Wrist fractures - Previous median nerve injury Presence of trigger points in muscles mimicking CTS symptoms

Design outcomes

Primary

Measure	Time frame
Severity of disease. Timepoint: At baseline and after 14 days. Method of measurement: Boston Carpal Tunnel Questionnaire.;Serum level of C-reactive protein (CRP). Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Total antioxidant capacity. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Total oxidant status. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Muscle nerve band. Timepoint: At baseline and after 14 days. Method of measurement: Electromyography.;Malondialdehyde. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Serum concentration of glutathione. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Superoxide dismutase activity. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Serum level of vascular cell adhesion molecule-1. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Erythrocyte sedimentation rate (ESR). Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Thyroid hormones. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Serum level of IL-6. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Serum level of TNF-a. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Serum level of TGF. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.	—

Measure

Time frame

Severity of disease. Timepoint: At baseline and after 14 days. Method of measurement: Boston Carpal Tunnel Questionnaire.;Serum level of C-reactive protein (CRP). Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Total antioxidant capacity. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Total oxidant status. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Muscle nerve band. Timepoint: At baseline and after 14 days. Method of measurement: Electromyography.;Malondialdehyde. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Serum concentration of glutathione. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Superoxide dismutase activity. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Serum level of vascular cell adhesion molecule-1. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Erythrocyte sedimentation rate (ESR). Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Thyroid hormones. Timepoint: At baseline and after 14 days. Method of measurement: biochemical kit of KiaZist Co.;Serum level of IL-6. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Serum level of TNF-a. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.;Serum level of TGF. Timepoint: At baseline and after 14 days. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits.

—

Secondary

Measure	Time frame
The average level of total cholesterol (HDL, LDL, TG) in the intervention and control groups. Timepoint: before and after intervention. Method of measurement: Kiazist biochemical kit.;The mean level of fasting blood sugar (FBS) among the intervention and control groups. Timepoint: Before and after intervention. Method of measurement: Kiazist biochemical kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Gholamreza Askari

Esfahan University of Medical Sciences

askari@mui.ac.ir+98 31 3792 3060

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026