Migraine. Migraine
Conditions
Interventions
Intervention 1: Intervention group: The patients will receive for 12 weeks a tablet containing 200 microgram selenomethionine (Health Burst) daily. Intervention 2: Control group: The patients will rec
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Migraine diagnosis based on International Classification of Headache Disorders-3 Age of 18 to 65 years At least two migraine attacks per month BMI of 18.5 to 30 kg/m2
Exclusion criteria
Exclusion criteria: Pregnancy or lactation Taking antioxidant supplements 3 month before the intervention Suffering from infectious disorders, cardiovascular diseases, diabetes, liver and kidney diseases, other neurological disorders including tension headache, epilepsy, Parkinson and multiple sclerosis .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical characteristics of migraine (frequency, severity, and duration of migraine headaches). Timepoint: At baseline and after 12 weeks. Method of measurement: Visual analogue scale questionnaire.;Oxidative stress (malondialdehyde, nitric oxide, total oxidant status and total antioxidant capacity). Timepoint: At baseline and after 12 weeks. Method of measurement: Kiazist biochemical kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mental health. Timepoint: At baseline and after 12 weeks. Method of measurement: DASS-21 questionnaire.;Quality of life. Timepoint: At baseline and after 12 weeks. Method of measurement: MSQ and HIT-6 questionnaires. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Gholamreza Askari
Esfahan University of Medical Sciences
Outcome results
None listed