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Effect of curcumin-piperine in patients with ischemic stroke

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indicators in patients with ischemic stroke in the rehabilitation phase: a double-blind clinical trial study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20121216011763N48
Enrollment
80
Registered
2020-12-18
Start date
2020-12-19
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke. Cerebral infarction

Interventions

Intervention 1: Intervention group: A daily curcumin-piperine capsule(500 mg curcumin + 5 mg piperine) will receive after meal for 12 weeks. Intervention 2: Control group: A daily placebo capsule(505

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: The person has had a stroke only once At least 3-6 months have passed since the stroke (subacute and chronic phase) NIHSS =5-24 diagnosis of stroke by CT-scan and MRI Age=20-65 years old BMI=18/5-35 Tendency to participate in the study

Exclusion criteria

Exclusion criteria: Taking anticoagulants such as aspirin, heparin, warfarin, etc. Taking antioxidant and multivitamin supplements and omega-3 supplements Having malignant diseases and cancers

Design outcomes

Primary

MeasureTime frame
HS-CRP. Timepoint: The beginning and the end of the study. Method of measurement: ELISA kit.;TAC. Timepoint: The beginning and the end of the study. Method of measurement: Laboratory method.;Fibrinogen plasma level. Timepoint: The beginning and the end of the study. Method of measurement: ELISA kit.;Lipid profile. Timepoint: The beginning and the end of the study. Method of measurement: Enzymatic method.;Systolic and diastolic blood pressure. Timepoint: The beginning and the end of the study. Method of measurement: Mercury Barometer.

Secondary

MeasureTime frame
Weight. Timepoint: The beginning and the end of the study. Method of measurement: Digital scale.;Waist Circumference (WC). Timepoint: The beginning and the end of the study. Method of measurement: Inelastic meters.;Body mass index (BMI). Timepoint: The beginning and the end of the study. Method of measurement: Dividing the weight into kilograms by squared height by meter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKosar Boshagh

Esfahan University of Medical Sciences

kboshagh71@gmail.com+98 21 6553 9905

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026