Condition 1: Migraine. Condition 2: Migraine. Migraine Migraine
Conditions
Interventions
Intervention 1: Intervention group: Daily melatonin 3 mg half an hour before bedtime for 8 weeks. Intervention 2: Control group: One placebo daily (50 mg starch) half an hour before bedtime for 8 week
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Women from the age of 18 to menopause Diagnosis of migraine by a neurologist Willing to work with the project
Exclusion criteria
Exclusion criteria: People with a history of overdose of analgesics according to IHS criteria for antidepressant abuse Pregnancy or breast-feeding History of significant complications or recent use of melatonin supplements Severe depression in the past year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Migraine symptoms (severity, frequency, duration of migraine). Timepoint: Week 0 and Week 8. Method of measurement: Questionnaire.;Serum levels of calcitonin-associated peptide (CGRP). Timepoint: Week 0 and Week 8. Method of measurement: Laboratory analysis (blood test). | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression, stress, anxiety. Timepoint: week 0 and week 8. Method of measurement: DASS-21questionnaire.;Quality of Life in Migraine Patients. Timepoint: week 0 and week 8. Method of measurement: Migraine –Specific Quality of Life(MSQ)questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Moradi
Esfahan University of Medical Sciences
Outcome results
None listed