The effect of phytosomal curcumin on fatty liver

Effect of phytosomal curcumin on lipid profile,fasting blood glucose, anthropometric indices, hepatic function and degree of steatosis, and liver fibrosis measured by fibroscan in non-alcoholic fatty liver patients: a double-blind clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20121216011763N39

Enrollment

Registered

2019-11-26

Start date

2020-04-20

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: phytosomal curcumin, 250 mg oral capsule, once daily for 12 weeks. Intervention 2: Control group: Placebo (maltodextrin) 250 mg orally, once daily for 12 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Willingness to participate in the study age 18-65 years Non-alcoholic fatty liver (Grade 1-3) diagnosed by previous ultrasound

Exclusion criteria

Exclusion criteria: Pregnancy and lactation Alcoholic fatty liver disease Tobacco consumption Heart, Lung and Kidney Diseases, Hepatitis, Cirrhosis, Biliary and Immune Disorders, Diabetes, Cushing's Syndrome Intake of lipid and glucose lowering drugs, Vitamin E and D, orthoedoxic acid, phenytoin, tamoxifen, lithium, corticosteroids and methotrexate Weight loss and bariatric surgery in the last year

Design outcomes

Primary

Measure	Time frame
Aspartate amino transferase. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic photometric.;Degree of liver fibrosis. Timepoint: Before intervention, end of intervention. Method of measurement: Fibroscan device.;Degree of liver steatosis. Timepoint: Before intervention, end of intervention. Method of measurement: Fibroscan device.;Alkaline amino transferase. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic photometric.	—

Measure

Time frame

Aspartate amino transferase. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic photometric.;Degree of liver fibrosis. Timepoint: Before intervention, end of intervention. Method of measurement: Fibroscan device.;Degree of liver steatosis. Timepoint: Before intervention, end of intervention. Method of measurement: Fibroscan device.;Alkaline amino transferase. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic photometric.

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Secondary

Measure	Time frame
TG. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;Tch. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;HDL. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;LDL. Timepoint: Before intervention, end of intervention. Method of measurement: Fried Wald Equation equation.;FBS. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;Weight. Timepoint: Before intervention, end of intervention. Method of measurement: Digital scale.;Waist. Timepoint: Before intervention, end of intervention. Method of measurement: Meters irreversible.;BMI. Timepoint: Before intervention, end of intervention. Method of measurement: Body Mass Index Formula.	—

Measure

Time frame

TG. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;Tch. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;HDL. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;LDL. Timepoint: Before intervention, end of intervention. Method of measurement: Fried Wald Equation equation.;FBS. Timepoint: Before intervention, end of intervention. Method of measurement: Enzymatic.;Weight. Timepoint: Before intervention, end of intervention. Method of measurement: Digital scale.;Waist. Timepoint: Before intervention, end of intervention. Method of measurement: Meters irreversible.;BMI. Timepoint: Before intervention, end of intervention. Method of measurement: Body Mass Index Formula.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamreza Askari

Esfahan University of Medical Sciences

askari@mui.ac.ir+98 31 3668 1378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 9, 2026