Rheumatoid Arthritis. Rheumatoid arthritis with rheumatoid factor
Conditions
Interventions
Intervention 1: Intervention group During the 3 months of our study, we used steroid and DMARD (methotrexate) and synbiotic. This supplement made by the Lactocare brand was made by the biomarker knowl
Sponsors
the University of medical sciences Esfahan
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Rheumatoid arthritis patients (based on ACR criteria) At least 3 months after the diagnosis of RA. At least 4 swollen joints which were in a stable status for at least 1 month, on MTX and prednisolone
Exclusion criteria
Exclusion criteria: Drug reaction and hypersensitivity patient dissatisfaction consumption of probiotic oral or medical in the last 2 weeks IBD intestinal perforation creatinine clearance by using the CKD-EPI equation of less than 40 mL/min per 1.73 m2 aspartate and alanine aminotransferase levels greater than twice the upper limit of normal active or recent hepatitis or cirrhosis plan for surgery in the next 3 months thyroid disorders Cushing's disease or syndrome malignant tumors, inadequately controlled diabetes mellitus or arterial hypertension serious infections, serious cardiac or respiratory diseases, leukopenia or thrombocytopenia, inadequate contraception, pregnancy or a plan for it in the next 3 months, breastfeeding, osteoporosis, use of cytotoxic or immunosuppressive drugs for 3 months before inclusion, current or past substance abuse (including tobacco) or alcohol use greater than 2 U/d and psychological illnesses or intellectual disorders that would preclude adherence to the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of disease activity. Timepoint: At the beginning of the study and 3 months after starting the drug. Method of measurement: Physical examination for the number of tender joint (T1) and swellen j (S1) and blood tests (ESR, CRP, ALT, Cr), calculate DAS28 according to ESR, Tender Joint, Sowllen joint and VAS dat. | — |
Countries
Iran (Islamic Republic of)
Contacts
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Esfahan University of Medical Sciences
Outcome results
None listed