Migraine. G43
Conditions
Interventions
Intervention 1: Intervention group: Two oral supplementation curcumin 500 mg are given for 8 weeks. Intervention 2: Control group: Two placebo (corn starch) 500 mg for 8 weeks.
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Aged 20-50 years Diagnose of migraine by neurologist willing to participate on study Lack of severe depression and anxiety and stress Not taking Vitamin and Antioxidant supplements (Vitamin E and C ? Selenium ? Zinc and Beta carotene) Not having tension headaches Not taking Anti migraine drugs The absence of severe chronic disease such as Cancer ? Hepatitis ? pancreatitis ? diabetes ? Thyroid disorders ? Kidney and Liver disease Having no inflammatory diseases or history of heart disease and stroke and taking anti-inflammatory drugs
Exclusion criteria
Exclusion criteria: Unwilling to participate in the study Use of antioxidant supplements, vitamins and anti-migraine drugs Chronic diseases and tension headaches Indication of allergic symptoms due to curcumin supplementation Pregnancy and lactation, or any major change in lifestyle or diet
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of migraine, migraine frequency and duration of headache. Timepoint: The beginning and the end of the study. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of IL-6, CGRP and TAC. Timepoint: The beginning and the end of the study. Method of measurement: Laboratory method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSheyda Rezaei
Esfahan University of Medical Sciences
Outcome results
None listed