Neutropenia. Agranulocytosis
Conditions
Interventions
Intervention 1: Ceftazidim 500 milligram intravenous every 6 hours and Amikacine 15 milligram/kilogram/day intravenous for 3 days. Intervention 2: Imipenem 500 milligram intravenous every 6 hours for
Treatment - Drugs
Ceftazidim 500 milligram intravenous every 6 hours and Amikacine 15 milligram/kilogram/day intravenous for 3 days
Imipenem 500 milligram intravenous every 6 hours for 3 days
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 95 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients aged more than 18 years with cancer; recent chemotherapy; oral temperature more than 38.3°c or more than 38 °c for 1 hour and neutrophil lower than 1500/micro liter. Exclusion criteria: pregnancy and breast feeding; use of antibiotic for at least 3 days before randomization; CNS infection; blastic crisis;coma; septic shock and definite origin for fever.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fever. Timepoint: daily for 3 days. Method of measurement: centigrade-termometer.;Culture. Timepoint: day 1-day 3. Method of measurement: colony/mm3-culture medium. | — |
Secondary
| Measure | Time frame |
|---|---|
| Convulsion. Timepoint: daily during treatment period. Method of measurement: history.;Renal failure. Timepoint: daily during treatment period. Method of measurement: milligram/deciliter-creatinin measurement. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Zamani
Arak University of Medical Sciences
Outcome results
None listed