Prophylactic effect of phenylephrine on post-spinal hypotension during cesarean section

Comparison of prophylactic infusion of phenylephrine with ephedrine for prevention of hypotension in elective cesarean section under spinal Anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012120911700N1

Enrollment

Registered

2013-07-21

Start date

2012-03-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Anesthesia, Hypotention. Other complications of spinal and epidural anaesthesia during the puerperium

Interventions

Intervention 1: Intervention group1: Infusion of 450 micrograms Phenylephrine in 250 milliliters of normal saline during 30 minutes before performing spinal anesthesia. Intervention 2: Intervention gr

Treatment - Drugs

Placebo

Intervention group1: Infusion of 450 micrograms Phenylephrine in 250 milliliters of normal saline during 30 minutes before performing spinal anesthesia

Intervention group 2: Infusion of 45 milligrams Ephedrine in 250 milliliters of normal saline during 30 minutes before performing spinal anesthesia

Control group::Infusion of 250 milliliters of normal saline during 30 minutes before performing spinal anesthesia

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: any healthy pregnant women with gestational age of 36 weeks or higher and non emergency cesarean section. Exclusion criteria: gestational age less than 36 weeks; emergency cesarean section; any contraindication of spinal anesthesia (patient refusal , coagulopathy , hemorrhage or hypovolemic shock) and unexpected events during surgery such a hemorrhage or sensory block level blow or higher then T4-T5 after spinal anesthesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Every 5 minute until fetal delivery,then every 5 minute throughout surgery. Method of measurement: Noninvasive blood pressure control with noninvasive mamometer.;Maternal complications(Dysrhythmias,nausea and vomiting,other complications) ting,other complications. Timepoint: Continuous Inspection. Method of measurement: Electrocardiogram, continuous Inspection.	—

Secondary

Measure	Time frame
Neonatal outcome. Timepoint: 1st and 5th minutes Apgar Scores after neonatal delivery. Method of measurement: 1st and 5th minutes Apgar Scoring system.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarnaz Moslemi Tabrizi

Tabriz University of Medical Sciences

moslemifa@gmail.com+98 41 1329 6295

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026