effect of low dose propofol and midazolam to prevent nausea and vomiting during caesarean section

The effect of subhypnoyic doses of propofol and midazolam to prevent nausea and vomiting during spinal anesthesia for Elective caesarean section

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012120810765N1

Enrollment

Registered

2013-08-06

Start date

2011-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nausea and vomiting during cesarean section under spinal anesthesia. Other complications of spinal and epidural anaesthesia during labour and delivery

Interventions

Intervention 1: In group 1 or placebo(Control) postdelivery, first normal saline iv injected, then infusion of NNormal salin establish until the end of surgery. Intervention 2: In group 2 or Interven

Treatment - Drugs

In group 1 or placebo(Control) postdelivery, first normal saline iv injected, then infusion of NNormal salin establish until the end of surgery.

In group 2 or Intervention post delivery, first propofol 20 mg intravenous injected, then infusion of propofol 1 mg/kg/h established until the end of surgery.

In group 3 or Midazolam post delivery, Midazolam 1 mg bulos intravenous injected, then infusion of Midazolam 1 mg/kg/h established until the end of surgery.

Eligibility

Sex/Gender

Female

Age

20 Years to 30 Years

Inclusion criteria

Inclusion criteria: ]Inclusion criteria:Elective cesarean, phisical status of class ASA 1 and 2, age 20-30 years Exclusion criteria: Gastrointestinal disease, history of management with anti emetic drugs in the past 24 h, patients who spinal anesthesia has cnterindication

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nausea and vomiting. Timepoint: after spinal anesthesia until 6 h. Method of measurement: the intencity of nausea and vomiting with Bellville score.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: the baseline of BP, after spinal anesthesia every 2 minute until 15 min, then every 5 min until the end of operation. Method of measurement: noninvasive by new tech monitoring set.;Sedation. Timepoint: In the end of operation. Method of measurement: With using of Modified Ramcy sedation scoring.;Total ephedrine consumption. Timepoint: In the end of operation. Method of measurement: Ephedrine consumption (mg).	—

Measure

Time frame

Blood pressure. Timepoint: the baseline of BP, after spinal anesthesia every 2 minute until 15 min, then every 5 min until the end of operation. Method of measurement: noninvasive by new tech monitoring set.;Sedation. Timepoint: In the end of operation. Method of measurement: With using of Modified Ramcy sedation scoring.;Total ephedrine consumption. Timepoint: In the end of operation. Method of measurement: Ephedrine consumption (mg).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Sousan Rasooli

Women's Reproductive Health Research Center, Tabriz University of Medical Sciences

rasooli_s@yahoo.com+98 41 1553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026