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Effect of Curcumin in treatment of diabetic complications

Effect of curcumin supplementation on serum levels of advanced glycation end products , tumor necrosis factor alpha and metabolic indices in patients with diabetic retinopathy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20121208011689N6
Enrollment
50
Registered
2018-09-30
Start date
2017-03-21
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

People with diabetic retinopathy. Diabetic retinopathy

Interventions

Intervention 1: Intervention group: Patients in this group will receive curcumin capsule for 8 weeks. curcumin capsule is used once a day with lunch. Intervention 2: Control group:Patients in this gro

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Desire to cooperate and sign informed consent form after full knowledge of the goals and method of implementation of the study Age between 40 to 70 years old People with diabetic retinopathy without insulin

Exclusion criteria

Exclusion criteria: Receiving insulin Cases of chronic diseases such as cardiovascular, renal and hepatic disorders Malabsorption syndrome and inflammatory bowel disease (Crohn's disease, celiac sproctomy, short stomach and biliary tract jejuni-ileal syndrome) Having certain physiological conditions like pregnancy and breastfeeding

Design outcomes

Primary

MeasureTime frame
Serum level of methylglyoxal. Timepoint: First of study and in the end of study. Method of measurement: Elisa.

Secondary

MeasureTime frame
Serum levels of Pentosidine. Timepoint: At the beginning of the study and 8 weeks later. Method of measurement: Elisa.;Serum level of Carboxymehtyllyzine. Timepoint: At the beginning of the study and 8 weeks later. Method of measurement: Elisa.;Serum level of tumor necrosis factor alpha. Timepoint: At the beginning of the study and 8 weeks later. Method of measurement: Elisa.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNima Radkhah

Tabriz University of Medical Sciences

N.radkhah@gmail.com+98 41 3335 0914

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026