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Granulocyte Colony-Stimulating Factor for Intrauterine Insemination (IUI)

Effects of Intrauterine Injection of Granulocyte Colony-Stimulating Factor (G-CSF) on Pregnancy Rate of Infertile Women Undergoing Intrauterine Insemination (IUI)

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201212079281N2
Enrollment
200
Registered
2017-05-06
Start date
2017-03-10
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertile women under mild ovary stimulation and IUI. Female Infertility

Interventions

Intervention 1: Clomiphene citrate 100 gr QD from 5th -9th day of cycle and gonadotropin (FSH), 50-150 unit will be added in 8th day of cycle till there is one follicle with diameter 18 mm in vaginal
Treatment - Drugs
Clomiphene citrate 100 gr QD from 5th -9th day of cycle and gonadotropin (FSH), 50-150 unit will be added in 8th day of cycle till there is one follicle with diameter 18 mm in vaginal sonography and
Clomiphene citrate 100 gr QD from 5th -9th day of cycle and gonadotropin (FSH), 50-150 unit will be added in 8th day of cycle till there is one follicle with diameter 18 mm in vaginal sonography

Sponsors

Vice chancellor for research of Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 20 and 40 years; unexplained infertility; candidate for intrauterine insemination (IUI) Exclusion criteria: Allergy to prostaglandins; medical history of liver disease or renal failure; asthma; pulmonary disorders; glaucoma; contraindication of G-CSF injection such as sickle cell anemia, neutropenia and autoimmune disorders; endometriosis; male infertility; decreased ovarian reserve; Asherman syndrome; diabetes mellitus (DM)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Endometrial thickness in IUI cycle under mild ovarian stimulation. Timepoint: on the day of HCG triggering. Method of measurement: Measuring endometrial thickness on the day of HCG triggering by vaginal sonography.

Secondary

MeasureTime frame
Chemical and Clinical pregnancy or miscarriag. Timepoint: 16 days after doing IUI. Method of measurement: Serum beta HCG and transvaginal sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Zahra Shomali

Shiraz University of Medical Sciences

Shomaliz57@yahoo.com+98 71 3227 9715

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 11, 2026