Melasma. Melasma
Conditions
Interventions
Intervention 1: Intervention 2: Vehicle cream in control group for 4 months, once in a day. Intervention 2: Intervention 1: Cysteamine cream in intervention group for 4 months, once in a day.
Placebo
Treatment - Drugs
Intervention 2: Vehicle cream in control group for 4 months, once in a day
Intervention 1: Cysteamine cream in intervention group for 4 months, once in a day
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: men and women aged 18 to 50 years; skin types III, IV, V, epidermal melasma diagnosis confirmed by a wood light; Melasma duration for more than 6 months. Exclusion criteria: dermal and mixed type of melasma; using OCP during the study and 3 months before entering the study; treatment with corticosteroids; hormonal disorders; pregnant and lactating mothers.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mexameter changes. Timepoint: Before intervention, 2 & 4 months after intervention. Method of measurement: Erythema & Melanin measured by Mexameter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient clinical improvement. Timepoint: Before intervention, 2 & 4 months after intervention. Method of measurement: Physician's global score (inspection & comparing the photos).;MASI Score. Timepoint: Before intervention, 2 & 4 months after intervention. Method of measurement: Physician's global score (inspection & comparing the photos).;MASI score. Timepoint: Before intervention, 2 & 4 months after intervention. Method of measurement: Erythema and pigment measured by Dermacatch. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Susan Farshi
Tehran University of Medical Sciences
Outcome results
None listed