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Effects of simvastatin on clomiphen response in clomiphen – resistant women with polycystic ovary syndrome

Effects of simvastatin on clomiphen response in clomiphen – resistant women with polycystic ovary syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201212043386N8
Enrollment
25
Registered
2012-12-10
Start date
2009-05-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

We enrolled 25 anovulatory PCOS women who failed to ovulate by using only CC . All patients received cyclic oral contraceptives (30µg of ethinyl estradiol and 150µg of desogestrol) from the 5th day of
Treatment - Drugs

Sponsors

Semnan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria: women who were 18-40 years of age, with a period of infertility more than 1.5 years and normal serum prolactin and thyroid function tests, they all had documented patent tubes by hysterosalpingography, had no other infertility factor, and failed to ovulate with a dose of CC of 150 mg /day for 5 days from day 3 of the period. The women who were diabetic, had hypertension or abnormal renal or liver function tests, and had undergone ovarian drilling were excluded from the study. Hirsutism was diagnosed when the Ferriman and Gallway score was >8(15). The diagnosis of PCOS was according to the Rotterdam Criteria

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Ovulation and pregnancy rates. Timepoint: after intervention. Method of measurement: BHCG and sonography.

Secondary

MeasureTime frame
Change in BMI,. Timepoint: After intervention. Method of measurement: BMI=WT(kg)/H2(m).;Endometrial thickness. Timepoint: On HCG day adminstration. Method of measurement: Sonography.;Size and numbers of follicles>18mm. Timepoint: On HCG day adminstration. Method of measurement: Sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzam Azargoon

Semnan University of Medical Sciences

a-azargoon@sem-ums.ac.ir+98 23 1446 0077

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026