Survey the effect of Glucose-Insulin-potassium on metabolic and hemodynamic parameters during orthotopic liver transplantation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20121204011662N16

Enrollment

Registered

2024-09-15

Start date

2024-10-01

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver transplantation. Surgical operation with transplant of whole organ as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Interventions

Intervention 1: Intervention group (GIK): After selection of target group, glucose-insulin-potassium (GIK) will be prepared as ??? cc dextrose water ??% plus ?? mEq potassium chloride and ?? unit re

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Adult patients with ASA grade I or II (American Society of Anesthesiology classification) Adult patients between 18 and 70 years old Adult patients who are candidate for Orthotopic liver transplantation

Exclusion criteria

Exclusion criteria: Allergy to the drugs used in the study Positive history of heart, kidney, Hyperkalemia and diabetes diseases.

Design outcomes

Primary

Measure	Time frame
Arterial blood gas (ABG). Timepoint: after anesthesia induction and intubation as baseline ABG and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: ABG (arterial blood gas) test.;Potassium. Timepoint: After anesthesia induction and intubation as baseline Potassium and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: Blood potassium test.;Blood sugar (BS). Timepoint: After anesthesia induction and intubation as baseline BS and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: Blood sugar test.;Cardiac output. Timepoint: After anesthesia induction and intubation as baseline Cardiac output and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: The PiCCO (Pulse index Contour Continuous Cardiac Output).;Vascular resistance. Timepoint: After anesthesia induction and intubation as baseline Vascular resistance and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: The PiCCO (Pulse index Contour Continuous Cardiac Output).	—

Measure

Time frame

Arterial blood gas (ABG). Timepoint: after anesthesia induction and intubation as baseline ABG and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: ABG (arterial blood gas) test.;Potassium. Timepoint: After anesthesia induction and intubation as baseline Potassium and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: Blood potassium test.;Blood sugar (BS). Timepoint: After anesthesia induction and intubation as baseline BS and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: Blood sugar test.;Cardiac output. Timepoint: After anesthesia induction and intubation as baseline Cardiac output and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: The PiCCO (Pulse index Contour Continuous Cardiac Output).;Vascular resistance. Timepoint: After anesthesia induction and intubation as baseline Vascular resistance and ? others will be fallowed in end of hepatectomy phase, end of unhepatic phase, and ?? minutes after hepatic artery declamping. Method of measurement: The PiCCO (Pulse index Contour Continuous Cardiac Output).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Akbari

Shiraz University of Medical Sciences

sahmeddini@sums.ac.ir+98 71 1231 8072

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026