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Comparison the effect of magnesium sulfate with pregabalin on prevention of the pain severity induced by remifentanil.

Comparison the effect of magnesium sulfate with pregabalin on prevention of remifentanil – induced hyperalgesia in patients undergoing rhinoplasty. A randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20121204011662N12
Enrollment
105
Registered
2018-02-27
Start date
2018-02-20
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain management following rhinoplasty.. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group: Patients in group A will receive 300 mg pregabalin one hour before entering operation room. Intervention 2: Intervention group: Patients in group B will receive 30

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: A total of 105 patients in the ASA class 1 who candidate for rhinoplasty will be enrolled in the study.

Exclusion criteria

Exclusion criteria: Exclusion criteria : History of the heart diseases , pulmonary diseases, liver diseases, kidney diseases, neurological and psychological disease, history of the allergy to drugs such as pregabalin, magnesium sulfate, remifentanil, history of alcohol and narcotics abuse, patients who suffering from chronic pain, those who used pain killer drugs 72 hours prior to anesthesia.

Design outcomes

Primary

MeasureTime frame
Severity of postoperative pain. Timepoint: In the first 6 hours postoperation, every hour and then 24 hours after operation. Method of measurement: Numerical Rating Scale.

Secondary

MeasureTime frame
Sedation Score. Timepoint: In the first 6 hours postoperation, every hour and then 24 hours after operation. Method of measurement: Ramsey Scale.;Incidence of nausea and vomiting. Timepoint: In the first 6 hours postoperation, every hour and then 24 hours after operation. Method of measurement: 0: No nausea and vomiting, 1: Nuasea without Vomiting, 2: Both Nausea and Vomiting.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ali Sahmeddini

Shiraz University of Medical Sciences

sahmeddin@sums.ac.ir+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026