Postoperative pain and Immune response. Other acute postprocedural pain
Conditions
Interventions
Intervention 1: Intervention group: 20 min before general anesthesia, patients received 2mg/Kg bolus dose of lidocaine then intravenous infusion(1.5 mg/Kg) of lidocaine with infusion pump will be sta
Treatment - Drugs
Placebo
Intervention group: 20 min before general anesthesia, patients received 2mg/Kg bolus dose of lidocaine then intravenous infusion(1.5 mg/Kg) of lidocaine with infusion pump will be started till end of
Control group: In this group 20 minutes before general anesthesia, patients received 2ml /Kg bolus dose of the physiologic saline then intravenous infusion(1.5 ml/Kg/hr) of the physiologic saline wi
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: All patients who will be candidate for elective mastectomy due to breast tumor
Exclusion criteria
Exclusion criteria: Emergency patient;History of cardiac arrhythmia;Diabetes mellitus; Immune suppressive drugs; Corticosteriods;NSAIDs,; Renal and Liver failure; Hypersensetivity to lidocaine or contraindication of use of lidocaine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of postoperative pain. Timepoint: Every 15 min in the recovery room, then 4, 8, 12,24 hr post operation in ward. Method of measurement: Visual analog Scale.;Immune system response. Timepoint: In the morning of operation and 24 hr post operation. Method of measurement: Interleukin 1 and 6 Kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients satisfaction from pain control managment. Timepoint: 24 following operation. Method of measurement: Totally unsatisfactory=0, unsatisfactory=1,None=2,Satisfy=3, Completely satisfy=4. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Ali Sahmeddini
Shiraz University of Medical Sciences
Outcome results
None listed