Comparasion between several ovarian stimulation protocols for infertility treatment

Comparing IVF outcomes in GnRH antagonist protocol during early and late follicular phase and GnRH antagonist protocol(flexible) and long GnRH agonist protocol in patients with polycystic ovary syndrome .

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012120311653N1

Enrollment

150

Registered

2013-07-16

Start date

2013-07-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovary syndrom. Nutritional and metabolic disorders in diseases classified elsewhere

Interventions

Intervention 1: In GnRH antagonist group with early and late follicular phase:Cetrorelix0.25mg starts on day1,2 gonadotropin stimulation and when atleast 2 follicles reach 13-14 mm and continues unti

Treatment - Drugs

In GnRH antagonist group with early and late follicular phase:Cetrorelix0.25mg starts on day1,2 gonadotropin stimulation and when atleast 2 follicles reach 13-14 mm and continues until HCG administr

In GnRH agonist (long protocol)group:superfact 0.5 mg starts from day21 prior menstrual cycle and 0.25 mg superfact with gonadotropin stimulation and continues until HCG administration.

In GnRH antagonist (flexible)protocol group: cetrorelix 0.25mg starts when atleast 2 follicules reach 13-14mmand continues until HCG administration.

Eligibility

Sex/Gender

Female

Age

20 Years to 38 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: PCOS patients based on Rotterdam criteria with IVF indication for their infertility ; Age 20-38 Y; Normal Sexual development and Normal puberty; Patients without cardiac and vascular -renal-hepatic disease ; FSH2 ; recurrent abortion >=2 in first trimester ; Cervical and uterine anatomical abnormality ; ovarian cysts ; Hydrosalpinx

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy. Timepoint: After intervention. Method of measurement: Sonography.	—

Secondary

Measure	Time frame
Biochemical pregnancy. Timepoint: After intervention. Method of measurement: HCG.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Mokhtar

Avicenna Infertility Treatment Center

s.mokhtar@avicenna.ac.ir+98 21 2261 7930

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026