Analgesia of Fentanyl and Ketamine during Propofol Injection

Comparison of Analgesia of Fentanyl with Ketamine during Injection of Propofol

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012112811597N1

Enrollment

Registered

2013-02-24

Start date

2013-04-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain during injection. Unspecified complication during therapeutic injection, transport and injection

Interventions

Intervention 1: Drug: Ketamine Dose: 0.1mg/kg IV Injection Number of using: Once Factory name: Rotexmedica Manufacturing Country's name: Germany Administration time: 45 seconds before Propofol admin

Treatment - Drugs

Placebo

Drug: Ketamine Dose: 0.1mg/kg IV Injection Number of using: Once Factory name: Rotexmedica Manufacturing Country's name: Germany Administration time: 45 seconds before Propofol administration

Drug: Fentanil Dose: 1mcg/kg IV Injection Number of using: Once Factory name: Chekad Manufacturing Country's name: Iran Administration time: 45 seconds before Propofol administration

Placebo: Normal Saline 0.9% Dose used: 2 ml IV Injection Number of using: Once Factory name: Samen Pharmacy CO. Manufacturing Country's name: Iran Administration time: 45 seconds before Propo

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: - The patient's satisfaction – Age between 20 and 60 years old. Exclusion criteria: - History of substance abuse; hypnotics or narcotics throughout 24 hours before the surgery - History of drug abuse, or alcohol- dependency - Contraindication of Propofol or Ketamine - High Intracranial Pressure

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain during propofol injection. Timepoint: Every 5 seconds after injection. Method of measurement: Verbal Rating Scale.	—

Secondary

Measure	Time frame
Sedation. Timepoint: Every 5 seconds after injection. Method of measurement: Watching.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNushin Runassi

Ahvaz Jundishapur University of Medical Sciences

runassi.n@ajums.ac.irmostafafatahi777@gmail.com+98 61 1432 5879

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026