Spasticity due to cerebral stroke. Sequelae of cerebral infarction
Conditions
Interventions
Intervention 1: For Tizanidine group: Tizanidine will be started with 2 mg/day orally and added 2 mg/week until the dose of 16 mg/day in week 16. Intervention 2: In Botulinum group, patients will be
Treatment - Drugs
For Tizanidine group: Tizanidine will be started with 2 mg/day orally and added 2 mg/week until the dose of 16 mg/day in week 16.
In Botulinum group, patients will be injected two doses of Botulinum (not more than 1000 units/dose) into the upper limb muscles with a 3-4 month time gap.
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (to have a history of cerebral stroke for at least 3 months ago; severity of spasticity more than 2 in Ashworth scale; to be older than 35 years old) Exclusion criteria: (patients with impairment in level or content of consciousness; to have systemic disorders such as Diabetes, hyperthyroidism, electrolyte disorders, renal failure; to be older than 70 years old)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Limbs Spasticity. Timepoint: in the start of the study for all the patients, week 16 (for Tizanidine) and 3 months after the last injection (for Botulinum). Method of measurement: Based on Ashworth scale.;Limb functional improvement. Timepoint: in the start of the study for all the patients, week 16 (for Tizanidine) and 3 months after the last injection (for Botulinum). Method of measurement: Based on ARAT scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Ghasemi
Tabriz University of Medical Sciences
Outcome results
None listed