Primary autoimmune hypothyroidism. Autoimmune thyroiditis
Conditions
Interventions
Intervention 1: 20 patients with primary autoimmune hypothyroidism will receive levothyroxine plus selenium tablet 200 microgram once a day for three months. Intervention 2: 20 patients with primary a
Treatment - Drugs
20 patients with primary autoimmune hypothyroidism will receive levothyroxine plus selenium tablet 200 microgram once a day for three months
20 patients with primary autoimmune hypothyroidism will receive levothyroxine only for three months
Sponsors
Vice chancellor for Research the Technology, Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (a) age of 18 to 75 years; (b) having primary autoimmune hypothyroidisms; (c) having anti-TPO >200 U/ml Exclusion criteria: (a) history of Thyroid surgery; (b) history of thyroid cancer; (c) hypothyroidism resulted from hyperthyroidism; (d) history of auto-immune disease and known rheumatologic diseases; (e) pregnancy; (f) renal failure; (g) subclinical hypothyroidism; (h) history of using radioactive iodine, anti thyroid medication, cytotoxic; immunosuppressive, glucocorticoid, amiodaron, lithium, interferon, and chemotherapy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of anti-TPO titer. Timepoint: ?After three months. Method of measurement: Through electrochemiluminescence using diasorin set and liaison kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| TSH. Timepoint: 3 months post intervention. Method of measurement: Laboratory.;T3. Timepoint: 3 months post intervention. Method of measurement: Laboratory.;T4. Timepoint: 3 months post intervention. Method of measurement: Laboratory.;Abdominal pain. Timepoint: 3 months post intervention. Method of measurement: With question.;Hair loss. Timepoint: 3 months post intervention. Method of measurement: With question.;Dizziness. Timepoint: 3 months post intervention. Method of measurement: With question.;Sensation of garlic smell. Timepoint: 3 months post intervention. Method of measurement: With question.;Tremor. Timepoint: 3 months post intervention. Method of measurement: With question.;Sweating. Timepoint: 3 months post intervention. Method of measurement: With question. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Jalal Poorolajal
Research Center for Health Sciences and Department of Epidemiology & Biostatistics
Outcome results
None listed