thalassemia. Beta thalassemia
Conditions
Interventions
Intervention 1: Intervention group: In this group spleen size(by sonography), retic, Hb, CBC, erythropoietin, BUN, Cr and Na-Cl will be checked at the beginning of the study. Then according to the pat
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Accept to participate Major or Intermedia thalassemia patient who is transfusion dependent and has splenomegaly No Other Hematologic problem except Thalassemia
Exclusion criteria
Exclusion criteria: Neurological problem or Cr more than 1.5 mg/dl Hx of Drug reaction to captopril or any contraindication for ACE inhibitor Hypotension ( Blood pressure less than 80 mmhg ) Neutropenia or thrombocytopenia partial or total Splenectomy Jak inhibitor usage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spleen size. Timepoint: 3 months interval till 9 months. Method of measurement: Sonographic measurement.;Hemoglobin level. Timepoint: 3 month interval till 9 month. Method of measurement: CBC.;Need for Blood Transfusion. Timepoint: Changes during 9 month. Method of measurement: Interval of Transfusion by month. | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythropoietin level. Timepoint: at the beginning and end of the Study. Method of measurement: Quantitative Chemiluminescent Immunoassay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamid Mohammadi
Shiraz University of Medical Sciences
Outcome results
None listed