Acute Myocardial Infarction. Acute Myocardial Infarction
Conditions
Interventions
Intervention 1: Intervention: Bolus dose of NAC 100 mg/kg then 10 mg/kg/hr for 12 hours- During the intervention NAC will be administered intracoronary. Intervention 2: Control group: Receive D5W in t
Treatment - Drugs
Placebo
Intervention: Bolus dose of NAC 100 mg/kg then 10 mg/kg/hr for 12 hours- During the intervention NAC will be administered intracoronary
Control group: Receive D5W in the same volume as NAC
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria:Myocardial infarction patients who were candidate of primary PCI . Exclusion Criteria:rescue pci; emergency for cardiac bypass ; cardiogenic shock; life expactancy less than 6 months; Age less than 18 years old; Uncontrolled hypertension; Thrombocytopenia; Malformation or aneurysm; sever chronic renal failure; Sever liver failure; sensitivity to sulfonamides ; Major surgery; Unsatisfactory to enter to study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiography findings of remodeling (LVEDV). Timepoint: Baseline and after a month. Method of measurement: Echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of MMP-9. Timepoint: Baseline and after a month. Method of measurement: Serum level-Elisa kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzita Hajhossein Talasaz
Tehran University of Medical Sciences
Outcome results
None listed