Atrial fibrillation. Atrial fibrillation and flutter
Conditions
Interventions
Intervention 1: Intervention 1: 60 mg/Kg MgSO4 via cardioplegic solution during cross clamping. Intervention 2: Intervention 2: 80 mg/Kg MgSO4 via cardioplegic solution during cross clamping. Interven
Prevention
Intervention 1: 60 mg/Kg MgSO4 via cardioplegic solution during cross clamping
Intervention 2: 80 mg/Kg MgSO4 via cardioplegic solution during cross clamping
Intervention 3: 100mg/Kg MgSO4 via cardioplegic solution during cross clamping
Sponsors
Vice chancellor for research of Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: signing informed consent; candidate for elective CABG based on angiography; use of cardiopulmonary bypass (CBP) during surgery; no previous history of any cardiac dysrhythmias that is under treatment ( including AF); hemodynamic stability ( MAP>50, heart rate between 50-110); age between 35&75 years old. Exclusion criteria: history of heart failure (Ejection Fraction less than 30%); more than 4 grafts; renal failure ( serum creatinine >1.5 in two consecutive test); hepatic failure ( liver function tests more than 1.5 times of normal value); history of COPD; hyperthyroidism; serum PH 7.55; postoperative MI; second or third degree AV block; need for pacemaker after surgery; reoperation for any reason; history of pervious cardiac surgery; anti-arrhythmic drugs consumption (except beta blocker).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atrial fibrillation. Timepoint: up to 3 days after operation. Method of measurement: ECG monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| PH. Timepoint: Before Before trial, during the operation,1st day, 2nd day and 3th day after operation, during the operation,1st day, 2nd day and 3th day after operation. Method of measurement: Laboratory kit.;K. Timepoint: Before Before trial, during the operation,1st day, 2nd day and 3th day after operation, during the operation,1st day, 2nd day and 3th day after operation. Method of measurement: Laboratory kit - mEq/L.;Mg. Timepoint: Before Before trial, during the operation,1st day, 2nd day and 3th day after operation, during the operation,1st day, 2nd day and 3th day after operation. Method of measurement: Laboratory kit - mg/dl. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Gholipour Baradari, MD
Mazandaran University of Medical Sciences
Outcome results
None listed