pre-diabetic patient. Impaired glucose tolerancePrediabetes
Conditions
Interventions
Intervention 1: People with pre-diabetes, a fasting blood sugar of 100 -125mg/ dL or a two-hour blood sugar between 140 to 199 mg/ dL - Range of BMI 25 to 34.9 Kg / m 2 - Age: 20 to 50 years. daily 3
Treatment - Other
People with pre-diabetes, a fasting blood sugar of 100 -125mg/ dL or a two-hour blood sugar between 140 to 199 mg/ dL - Range of BMI 25 to 34.9 Kg / m 2 - Age: 20 to 50 years. daily 3 g L-arginine (3
People with pre-diabetes, a fasting blood sugar of 100 -125mg/ dL or a two-hour blood sugar between 140 to 199 mg/ dL - Range of BMI 25 to 34.9 Kg / m 2 - Age: 20 to 50 years. daily 3 g placebo(3 caps
Sponsors
Vice chancellor for research,Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: A) Inclusion criteria: - tendency to cooperate with research project - Newly diagnosed individuals with pre-diabetes - People with pre-diabetes, a fasting blood sugar of 100 -125mg/ dL or a two-hour blood sugar between 140 to 199 mg/ dL - Range of BMI 25 to 34.9 Kg / m 2 - Age: 20 to 50 years; B) Not allowed to inter criteria: - Have not past medical history of chronic diseases such as cardiovascular disease, liver disease, thyroid disease, chronic infection, heart attack or stroke in the previous years .- Taking lipid-lowering drugs, blood sugar-lowering drugs, estrogen or progesterone, antibiotics during past year ,- Taking any supplements such as L - arginine during the 2 months prior to the study- Smoking - pregnancy or lactation, or menopause - alcohol intake; C) Exclusion Criteria: - Non-compliance supplements taking (more than 10% of supplements it is not been taken .) - The existence of any of the criteria Not allowed to inter criteria - not wanting to continued cooperation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glutathione peroxidase activity level. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit).;Glutathione reductase activity. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit).;Superoxide dismutase activity. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit).;Total antioxidant capacity. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit). | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum concentrations of arginine. Timepoint: Before and 2 months after supplementation. Method of measurement: blood testing.;Weight. Timepoint: Before and 2 months after supplementation. Method of measurement: Use Scale With Accuracy 100g.;Height. Timepoint: Before and 2 months after supplementation. Method of measurement: Tape mete Installed on the wall.;BMI(Body Mass Index). Timepoint: Before and 2 months after supplementation. Method of measurement: Calculation:Weight (kg) / squared height (m).;Waist circumference. Timepoint: Before and 2 months after supplementation. Method of measurement: Tape meter.;Hip circumference. Timepoint: Before and 2 months after supplementation. Method of measurement: Tape meter.;Waist to Hip ratio. Timepoint: Before and 2 months after supplementation. Method of measurement: Calculation.;Energy intake. Timepoint: Before supplementation. Method of measurement: 24 hour recall.;Carbohydrate intake. Timepoint: Before supplementation. Method of measurement: 24 hour recall.;Protein intake. Timepoint: Before supplementation. Method of measurement: 24 hour recall.;Lipid intake. Timepoint: Before supplementation. Method of measurement: 24 hour recall.;Cholesterol intake. Timepoint: befor supplementation. Method of measurement: 24 hours recall.;Fiber intake. Timepoint: befor supplementation. Method of measurement: 24hours recall.;Saturated fatty acid intake. Timepoint: Before supplementation. Method of measurement: 24 hour recall.;Mono unSaturated fatty acid intake. Timepoint: Before supplementation. Method of measurement: 24 hour recall.;Polyunsaturated fatty acids intake. Timepoint: Before supplementation. Method of measurement: 24 hour recall. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSiavash Fazelian
Tehran University of Medical Sciences
Outcome results
None listed