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The effect of creatine supplementation combined with resistance training on cellular health indicators, mood disorders, and sleep quality

Efficacy of Creatine Supplementation Combined with Resistance Training on Indicators of Cell Health, Mood Disorders, and Sleep Quality in Healthy Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20121110011421N7
Enrollment
50
Registered
2025-09-12
Start date
2025-08-04
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Mood disorders. Condition 2: Sleep disorders. Persistent mood [affective] disorders Sleep disorders

Interventions

Intervention 1: Intervention group: For 8 weeks, they received Karen Company creatine (5 grams daily after training, also used on non-training days) along with an isocaloric diet (with the same percen

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 48 Years

Inclusion criteria

Inclusion criteria: Healthy adults (male and female) aged 18-48 years Healthy active adults with at least 3 months of resistance exercise (bodybuilding) history Resident of Tehran

Exclusion criteria

Exclusion criteria: The presence of metabolic diseases such as diabetes and high blood pressure, viruses such as influenza and coronavirus, and musculoskeletal diseases such as osteoporosis and rheumatoid arthritis. Taking medications that cause changes in metabolism and absorption: such as diuretics, amphetamines, thyroid hormones, topiramate, orlistat, and corticosteroids Following specific diets and taking dietary, exercise, and caffeine supplements Participation in professional sports Pregnant and breastfeeding women

Design outcomes

Primary

MeasureTime frame
Phase angle score. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Bioimpedance.;Pittsburgh Questionnaire Score. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Pittsburgh Questionnaire Score.;Brums Questionnaire Score. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Brums 32-questionnaire.

Secondary

MeasureTime frame
Waist Circumference. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Non-stretching tape measure.;Body Mass Index. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Dividing the weight into kilograms by squared height meters.;Body fat percentage. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Bioimpedance.;Physical activity. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Met-International Physical Activity Questionnaire.;Total body water. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Bioimpedance.;Intracellular water. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Bioimpedance.;Extracellular water. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Bioimpedance.;Lean body mass. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Bioimpedance.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Kurosh Djafarian

Tehran University of Medical Sciences

kdjafaran@tums.ac.ir+98 21 8897 3901

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026