prediabetic. Prediabetes
Conditions
Interventions
Intervention 1: Intervention group: People with prediabetes who follow a ketogenic diet for 13 weeks will receive. Intervention 2: Control group: Healthy people who follow a ketogenic diet for 13 week
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: overweight(BMI=25-29.9) and obese (BMI = 30) Male and female Age over 18 years
Exclusion criteria
Exclusion criteria: Smoking and Alcohol drinking Taking OCP drugs, anti-androgens, metformin, lipid and blood pressure lowering drugs Pregnancy and breastfeeding Women who intend to become pregnant or take drugs such as chloramifel, letrozole and gonadotropin Menopausal women Suffering from other diseases such as kidney disease, liver disease, cancer, heart disease and acute and chronic infectious diseases, type 1 and 2 diabetes, Cushing's disease, acromegaly, gigantism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Mettler Toledo balance.;HOMA-IR. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: HOMA- IR= insulin × glucose/405. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index. Timepoint: Before intervention and 13weeks after intervention. Method of measurement: Dividing the weight into kilograms by squared height by meter.;Fasting blood sugar. Timepoint: Before intervention and 13weeks after intervention. Method of measurement: Cobas Integra.;HOMA-ß; homeostatic model assessment of beta cell function. Timepoint: Before intervention and 13weeks after intervention. Method of measurement: HOMA-ß=360 × insulin/[glucose – 63].;Total cholesterol. Timepoint: Before intervention and 13weeks after intervention. Method of measurement: Cobas integra.;Triglyceride. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Cobas integra.;Low density lipoprotein-cholesterol. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Cobas integra.;High density lipoprotein-cholesterol. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Cobas integra.;Interleukin-10. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: ELISA kit.;Alkaline Phosphate. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Cobas Integra.;Malondialdehyde. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: spectrophotometer.;Alanine transferase. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: spectrophotometer.;Aspartate transferase. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Cobas Integra.;Blood urea nitrogen. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Cobas Integra.;Creatinine. Timepoint: Before intervention and 13 weeks after intervention. Method of measurement: Cobas Integra.;Urea. Timepoint: Before intervention and 13weeks after intervention. Method of measurement: Cobas Integra analyze.;Uric Acid. Timepoint: Before intervention and 13w | — |
Countries
Iraq
Contacts
Public ContactDr Kurosh Djafarian
Tehran University of Medical Sciences
Outcome results
None listed