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Evaluating the changes in outcome and serum metabolic biochemical parameters after oral Simvastatin administration in patients with poly cystic ovary syndrome undergoing IVF

Oral simvastatin effect on reproductive outcomes and biochemical metabolic parameters in PCOS patients undergoing IVF

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2012110811408N1
Enrollment
40
Registered
2013-01-30
Start date
2013-02-19
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poly Cystic Ovarian Syndrom. Sclerocystic ovary syndrome

Interventions

Intervention 1: Tab Simvastatin group 20 mg daily and Tab Metformin 500 mg daily for 8 week. Intervention 2: Tab Metformin 500 mg daily for 8 week.
Treatment - Drugs
Tab Simvastatin group 20 mg daily and Tab Metformin 500 mg daily for 8 week
Tab Metformin 500 mg daily for 8 week

Sponsors

Vice Chancellor for Research and Technology of Hamadan University of Medical Sciences and Health ser
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 45 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: All patients in reproductive age with pcos that refer to infertility clinic of fatemieh hospital of Hamadan, that agreed to participate in the study and complete the informed consent, and without history of endocrine disease, Recent use of lipid-lowering drugs and statins. exclusion criteria: don't referring After getting treatment, arbitrary discontinuation of treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
HDL. Timepoint: before of study and the fourth and eighth weeks. Method of measurement: with Biochemical laboratory techniques and in mg per deciliter.;LDL. Timepoint: before of study and the fourth and eighth weeks. Method of measurement: with Biochemical laboratory techniques and in mg per deciliter.;TG. Timepoint: before of study and the fourth and eighth weeks. Method of measurement: with Biochemical laboratory techniques and in mg per deciliter.;Testestroon. Timepoint: before of study and the fourth and eighth weeks. Method of measurement: with Biochemical laboratory techniques and in mg per deciliter.;GTT. Timepoint: before of study and the fourth and eighth weeks. Method of measurement: with Biochemical laboratory techniques and in mg per deciliter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Somayeh Enayati

Hamadan University of Medical Sciences and Health services

somayeh2.enayati@gmail.comsampad.hamedan@gmail.com+218 8968966

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026