Condition 1: Craniotomy of supratentorial lesion. Condition 2: Craniotomy of supratentorial lesion. Condition 3: Craniotomy of supratentorial lesion. Brain, supratentorial ????? ????? ??? Brain, supratentorial
Conditions
Interventions
Intervention 1: In the case group with last skin suture, infusion of propofol will be ceased but the infusion of remifentanil continued with the half dose of surgery time until response to verbal stim
Prevention
Placebo
In the case group with last skin suture, infusion of propofol will be ceased but the infusion of remifentanil continued with the half dose of surgery time until response to verbal stimulation by patie
In the control group, with the conclusion of surgery both drugs (propofol & remifentanil) will be discontinued and for blinding infusion of normal saline as placebo will starts.
Sponsors
Research Deputy of Medicine Faculty, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients who candidated to supratentorial craniotomy, Age from 18 to 65 years, ASA physical class I-II, preoperative GCS > 13 Eexclusion criteria: age> 65 II, GCS< 13, any allergy to the drugs of study, history of smoking, COPD, chronic cough, asthma, HTN, difficult airway and recent upper respiratory tract infections
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coughing & bucking intensity. Timepoint: during tracheal extubation. Method of measurement: Minogue Scale.;Mean Arterial Pressure. Timepoint: Each 2 minutes from last skin suture or Mayfield opening until extubation and each 2 minutes after extubation until 10 minute later/each 5 minutes until 15 minute later in recovery room. Method of measurement: Automatic noninvasive sphigmomanumeter.;Heart rate. Timepoint: Each 2 minutes from last skin suture or Mayfield opening until extubation and each 2 minutes after extubation until 10 minute later/each 5 minutes until 15 minute later in recovery room. Method of measurement: Pulse oximeter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time interval to awakening after discontinuing of anesthesia drug. Timepoint: Verbal stimulation every min after discontinuing of propofol. Method of measurement: Time to opening of eye with stimulation by cornometer.;Nausea & vomiting pervalance and intensity. Timepoint: Each 15 minutes until 1 hour in recovery room. Method of measurement: Four points score: 1 no sign, 2 mild, 3 moderate, 4 severe.;Concsiousness level. Timepoint: Each 15 minutes until 1 hour in recovery room. Method of measurement: GCS (Glasco coma scale).;Reoperation incidance rate. Timepoint: Till 48 houres after operation. Method of measurement: Sergeon's decision.;Arrythemia incidance rate. Timepoint: After the last suture or Mayfield opening till O.R abondonment. Method of measurement: Contineous ECG monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Hossein Bagheri Aghdam MD.
Tehran University of Medical Sciences
Outcome results
None listed