Comparison of pressure versus volume control ventilation in one lung ventilation

Comparison of the effect of two Pressure and Volume control ventilation during one lung ventilation in thoracic surgeries on the gas exchanges and the respiratory mechanical variables

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20121107011398N15

Enrollment

Registered

2022-01-03

Start date

2022-01-10

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracic surgery.

Interventions

Intervention 1: Intervention group: In the intervention group after induction of anesthesia and tracheal intubation with a left double lumen endotracheal tube, with the start of surgery, one-lung pre

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients candidates for thoracic surgery under one-lung ventilation ASA physical class < or = class III Patients with a body mass index between 20 - 35

Exclusion criteria

Exclusion criteria: Severe preoperative hypoxemia (SPo2 lower than 88% with room air) Patient dissatisfaction

Design outcomes

Primary

Measure	Time frame
Arterial blood oxygen pressure (PaO2). Timepoint: Before starting one-lung ventilation and for second time, 30 min after start of one-lung ventilation. Method of measurement: Arterial blood gas analysis.;Peak airway pressure. Timepoint: After tracheal intubation and then every 15 min during one-lung ventilation. Method of measurement: By airway pressure monitoring device included in anesthesia machine.;End-tidal pressure of CO2. Timepoint: Every 15 min during surgery. Method of measurement: By Capnograph monitoring.	—

Measure

Time frame

Arterial blood oxygen pressure (PaO2). Timepoint: Before starting one-lung ventilation and for second time, 30 min after start of one-lung ventilation. Method of measurement: Arterial blood gas analysis.;Peak airway pressure. Timepoint: After tracheal intubation and then every 15 min during one-lung ventilation. Method of measurement: By airway pressure monitoring device included in anesthesia machine.;End-tidal pressure of CO2. Timepoint: Every 15 min during surgery. Method of measurement: By Capnograph monitoring.

—

Secondary

Measure	Time frame
Dynamic compliance of respiratory system. Timepoint: After tracheal intubation and then every 15 min during one-lung ventilation. Method of measurement: Using the standard formula and tidal volume divided in airway pressure.;Respiratory dead space. Timepoint: After tracheal intubation and then 30 min after one-lung ventilation starting. Method of measurement: Calculation by the use of arterial and end tidal PCo2 pressure.	—

Measure

Time frame

Dynamic compliance of respiratory system. Timepoint: After tracheal intubation and then every 15 min during one-lung ventilation. Method of measurement: Using the standard formula and tidal volume divided in airway pressure.;Respiratory dead space. Timepoint: After tracheal intubation and then 30 min after one-lung ventilation starting. Method of measurement: Calculation by the use of arterial and end tidal PCo2 pressure.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Ghodraty

Iran University of Medical Sciences

ghodrati.mr@iums.ac.ir+98 21 8894 6762

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026