Effect of Silymarin, Metformin, and life style in non-alcoholic fatty liver disease

Effect of silymarin, metformin, and life style in patients with non-alcoholic fatty liver disease in Marvdasht Hospital

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20121105011375N5

Enrollment

Registered

2018-05-10

Start date

2018-05-22

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver. Nonalcoholic steatohepatitis (NASH)

Interventions

Intervention 1: Intervention group: lifestyle modification and Metformin 500 mg/day for 3 months. Intervention 2: Intervention group: lifestyle modification and Silymarin 140 mg/day for 3 months. Inte

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with NAFLD confirmed by performing liver sonography Increased levels of liver enzymes AST and ALT

Exclusion criteria

Exclusion criteria: History of alcohol consumption Diabetes Chronic liver disease Use of drugs such as statin, fibrate

Design outcomes

Primary

Measure	Time frame
Liver function test. Timepoint: Before intervention, 3 months after intervention. Method of measurement: ELISA.	—

Secondary

Measure	Time frame
Body Mass Index. Timepoint: Before intervention, 3 months after intervention. Method of measurement: By BMI Formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaedeh Pourfarmanbar

Shiraz University of Medical Sciences

taranehh99@yahoo.com+98 71 3230 5645

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026