prediabetes. Abnormal glucose tolerance test
Conditions
Interventions
Intervention 1: intervention group:melatonin supplement 3mg for 1 month befor sleep. Intervention 2: control group: corn starch placebo before sleep.
Prevention
Placebo
intervention group:melatonin supplement 3mg for 1 month befor sleep
control group: corn starch placebo before sleep
Sponsors
Vice-chancellor for research -Tehran University of Medical Science
Eligibility
Sex/Gender
All
Age
35 Years to 50 Years
Inclusion criteria
Inclusion criteria: Requirements to select patients:The patients whose affliction with prediabetes are confirmed and their blood sugar before breakfast is in the range of 100-125;age between 35 and 50;BMI = 25 kg/m2;Having normal physical activities ;Interested in the research project Factors preventing patients from being included in the study ,Smoking, and using alcohol and other drugs ;Professional athletes ,Persons used the drugs reducing blood lipid, heart drugs, hypertension drugs, diuretics, vitamin supplements or any antioxidant three months before the intervention ,Using anti-inflammatory drugs, the drugs or materials having interference with melatonin supplement, such as vafarin, within three months before the intervention ;Having a record of ischemic heart disease, stroke, kidney failure, cancer, chemotherapy, radiotherapy and other diseases in which free radicals are a cause ;Women in the period of pregnancy and breastfeeding;Women with premature menopause;People working at night shifts ;People engaged in shift working Removing patients from the population:Changing drug diet ;Adopting special diets;Ceasing intake of the supplement for three days
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity of SOD enzyme. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,U/gHb,kit.;Activity of CAT enzyme. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,k/gHb,kit.;TAC serum. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,Mmol/ml,kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: befor intervention,1 month after intervention. Method of measurement: Sphygmomanometer,mmHg.;Fasting blood sugar. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,Mg/dl.;Height. Timepoint: before intervention. Method of measurement: stadiometer,cm.;Weight. Timepoint: before intervention,30 days after intervention. Method of measurement: Scale ,kg.;BMI. Timepoint: befor intervention,30 days after intervention. Method of measurement: calculate, kg/cm2. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzam Mohebi
Department of Nutrition and Biochemistry
Outcome results
None listed