Effect of clonidine in total sedative agents use in the intensive care unit

The impact of adding clonidine in total sedative agents use in mechanically ventilated patients in the intensive care unit: A prospective, randomized, double blind study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012102910178N3

Enrollment

Registered

2012-11-14

Start date

2012-10-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanically ventilated patients in the intensive care unit. Diseases of the respiratory system

Interventions

Intervention 1: clonidine 0.1mg TDS orally day 1 then 0.2mg TDS orally for total of 7 days. Intervention 2: Placebo.

Treatment - Drugs

Placebo

clonidine 0.1mg TDS orally day 1 then 0.2mg TDS orally for total of 7 days

Eligibility

Sex/Gender

All

Age

18 Years to 149 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: all patients on mechanical ventilation Exclusion criteria:mechanical ventilation less than 3 days; sepsis; volume depletion; second or third degree atrioventricular node block; GFR < 15 ml/min; hepatic failure (Child Pough score: severe); GCS < 8; use of clonidine during past month

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Total sedative agents use including opiods, midazolam, other benzodiazepines and propofol. Timepoint: Daily. Method of measurement: Total daily dose.	—

Secondary

Measure	Time frame
Clonidine blood level. Timepoint: day 4 and 7. Method of measurement: ELisa kit.;Duration of mechanical ventilation. Timepoint: Daily. Method of measurement: Daily.;Duration of ICU LOS. Timepoint: Daily. Method of measurement: Daily.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Sistanizad

Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences

sistanizadm@sbmu.ac,ir+98 21 8820 0087

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026