Idiopathic thrombocytopenic purpura. Idiopathic thrombocytopenic purpura (Evans syndrome)
Conditions
Interventions
Intervention 1: Intervention 1. IVIG, 1 gr/kg, 8 hours IV infusion, single dose. Intervention 2: Intervention 2. Rhophylac, 50 µg/kg, 15 minutes IV infusion with 100 ml normal saline, single dose.
Treatment - Drugs
Intervention 1. IVIG, 1 gr/kg, 8 hours IV infusion, single dose.
Intervention 2. Rhophylac, 50 µg/kg, 15 minutes IV infusion with 100 ml normal saline, single dose.
Sponsors
Arak University of Medical Sciences, Vice Chancellor for Research
Eligibility
Sex/Gender
All
Age
1 Years to 15 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Age upper 1 year and lower 15 years old in patients with acute or chronic ITP 2. Platelets <30000 at the time of treatment 3. Patients entered in the study that parental consent was obtained Exclusion criteria: 1. Splenectomy patients 2. Hemoglobin below 10 g/dL 3. Patients who have been treated with IVIG or rhophylac in the past three weeks 4. Patients with renal insufficiency 5. Total bilirubin above 2 mg per deciliter and higher than normal liver enzymes 6. Patients who have a positive direct Coombs test 7. Patients who are infected with HIV or hepatitis C or B 8. Patients with lupus erythematosus 9. Patients with cardiovascular disease 10. Rh-negative patients
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet count. Timepoint: Sixth hour and days 3, 7, and 14 after treatment. Method of measurement: complete blood count.;Fever. Timepoint: since 6 hours after infusion. Method of measurement: mercury thermometer.;Hemolysis. Timepoint: 6 hours after infusion. Method of measurement: complete blood count.;Allergic reaction. Timepoint: 6 hours after infusion. Method of measurement: clinical manifestations. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Peyman Azadmanesh
Arak University of Medical Sciences
Outcome results
None listed