Myocardial Infarction (MI). ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group will receive probiotic capsule for 12 weeks. Probiotic capsule is a containing 1.6× 109 CFU of lactobacillus rhamnosus (a product by TacZist
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients with Myocardial Infarction and successful precancerous intervention (PCI) age range from 30-60 years body mass index (BMI) higher than 25 kg/m2 will be included in the study.
Exclusion criteria
Exclusion criteria: patient with chronic renal failure; hemodialysis previous myocardial infraction patients receiving immunosuppressive, anti-inflammatory and corticosteroid drugs; history of supplementation with pre/pro/symbiotic or antioxidants during previous two months will not be included in the study. with Being irritable bowel syndrome; Crohn's disease or ulcerative colitis Heart failure (functionclass III and IV), Heart valve diseases Subjects with diabetes
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Dietary inflammatory index (DII ). Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: via Food Frequency Questionnaire. | — |
Primary
| Measure | Time frame |
|---|---|
| Depression severity. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Beck Depression Inventory scale.;Physical activity level. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Via IPAQ questionnaire.;Quality of life. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Via MacNew questionnaire.;Lipid profile including HDL, LDL, TC and TG. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: HDL, TC and TG via enzymatic kit, LDL via friedewald equation.;Serum levels of Gut metabolites (TLR4, Zonulin and LPS). Timepoint: Baseline and 12 weeks after intervention. Method of measurement: TLR4, Zonulin and LPS measurements by ELISA.;Oxidative stress indices. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Measurement of serum levels of Total antioxidant capacity (TAC) and malondialdehyde (MDA) by spectrophotometry.;Serum level of Gut metabolite ( TMAO). Timepoint: Baseline and 12 weeks after intervention. Method of measurement: TMAO level by MS / MS.;Inflammatory stress indices. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Measurement of inflammatory indices of hs-CRP, IL1B and IL-10 in serum by ELISA.;Level of ox-LDL. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Measurement of ox-LDL via ELISA kit.;Levels of TGF. Beta. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Measurement of TGF. Beta via ELISA kit.;Levels of NTpro BNP. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Measurement of NTpro BNP via ELISA kit.;Levels of MMP-9. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Measurement of NTpro BNP via ELISA kit.;Levels of Procolagen I. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Measurement of Procolagen I via ELISA kit.;Echocardiographic indices of cardiac remodeli | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJalal Moludi
Tabriz University of Medical Sciences
Outcome results
None listed