A comparison of effect of pretreatment with intravenous dexamethasone, intravenous ketamine and their combination for suppression of remifentanil induced cough

A comparison of effect of pretreatment with intravenous dexamethasone, intravenous ketamine and their combination for suppression of remifentanil induced cough: a randomized, double-blind, placebo controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201210255362N4

Enrollment

120

Registered

2012-11-11

Start date

2011-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cough. cough

Interventions

Intervention 1: Group ketamine: 10 mg of ketamine in 3ml volume+3 ml saline was injected. Intervention 2: Group saline: the same volume of saline was injected . Intervention 3: Group combination of k

Prevention

Group ketamine: 10 mg of ketamine in 3ml volume+3 ml saline was injected.

Group saline: the same volume of saline was injected .

Group combination of ketamine and dexamethasone: 10 mg of combination of ketamine and dexamethasone in 3ml volume+3 ml saline was injected.

Group dexamethasone:10 mg of dexamethasone in 3ml volume+3 ml saline was injected .

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: patient satisfaction to enter study; body weight less than 20% of ideal body weight; no history of smoking, chronic obstructive lung diseases, bronchial asthma, respiratory tract infection or allergy to the study drugs; treated with angiotensin converting enzyme inhibitor, bronchodilators or steroid Exclusion criteria: any changes in anesthesia technique

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of cough. Timepoint: 5 minute After injection of remifentanil. Method of measurement: counting.;Incidence of cough. Timepoint: 5 minute After injection of remifentanil. Method of measurement: watch.;Onset time of cough. Timepoint: 5 minute After injection of remifentanil. Method of measurement: watch.	—

Secondary

Measure	Time frame
Haemodynamic. Timepoint: immediately after arriving at operation room,immediately after injection of remifentanil,immediately after injection of tiopantal. Method of measurement: watch.;Side effect. Timepoint: every hour. Method of measurement: watch.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadreza Safavi

Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, I

safavi@med.mui.ac.ir+98 31 1625 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026