Effects of Transcranial Direct Current Stimulation (tDCS) over Craving in abstinence methamphetamine user

Online Transcranial DC Stimulation (tDCS) over the Dorsolateral Prefrontal Cortex and Cue Induced Craving in Methamphetamine Dependents: A double-blind, sham-controlled study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012102311234N1

Enrollment

Registered

2012-11-28

Start date

2012-07-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Methamphetamine dependency. Dependence syndrom, Mental and behavioural disorders due to use of other stimulants, including methamphethamine

Interventions

Intervention 1: Direct current was delivered from a battery-driven, constant current stimulator (ActivaDoseII. Iontophoresis Delivery Unit, P/N00148-Rev A, ActivaTek, Inc. Salt Lake City UT 84119 USA)

Treatment - Other

Direct current was delivered from a battery-driven, constant current stimulator (ActivaDoseII. Iontophoresis Delivery Unit, P/N00148-Rev A, ActivaTek, Inc. Salt Lake City UT 84119 USA) and transferred

In this study, control group received sham transcranial direct current stimulation(tDCS). For sham stimulation, the same methods of placing anode and cathode were used, however, the stimulator was ra

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria; Having a history of at least 12 months methamphetamine dependence, based on DSM-IV-TR criteria; before entering the treatment program and also being abstinence from any drugs except cigarettes, at least for the last week; We tested subjects’ cue-reactivity in the recruitment process based on their subjective reports of craving feeling after exposure to 2 drug-related cues, which were not included in the main craving task; Subjects were excluded if at least their mean craving self-report was below 20 out of 100. Exclusion Criteria: Individuals with any current or past clinical significant neurologic disorder; usage of central nervous system-effective medication; history of epilepsy; brain surgery;tumor; intracranial metal implantation; clinically significant head trauma; or any clinical significant psychiatric disorder (in axis I, except substance-related disorders).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Methamphetamine Craving. Timepoint: before intervention, online with intervention and After intervention. Method of measurement: Computerized Cue-induced Craving Assessment Task(CCIC), Desires for Drug Questionnaire (DDQ).	—

Secondary

Measure	Time frame
Mood Status. Timepoint: It is assessed before and after brain stimulation and induced craving, in both sessions. Method of measurement: Positive and Negative Affect Scale(PANAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Shahbabaie

Iranian institute for Cognitive Science Studies

shahbabai.a@iricss.org+98 21 8880 2063

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026