Liver Cirrhosis. Other and Unspecified cirrhosis of liver
Conditions
Interventions
Intervention 1: Intervention group: Participants in the intervention group will receive Pentoxifylline 400 mg tablets (Amin Pharmaceutical Co., Iran).Pentoxifylline is a methylxanthine derivative with
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adults (=18 years) with cirrhosis and fatigue symptoms Willingness to participate and provide informed consent. Fatigue Severity Scale (FSS) equal and greater than 28 patients with Cirrhosis child pugh score A and B
Exclusion criteria
Exclusion criteria: patients with Cirrhosis child pugh score C Known allergy to Pentoxifylline or xanthine derivatives Recent cerebral or retinal hemorrhage Significant drug interactions (e.g., warfarin, theophylline)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue Severity. Timepoint: before intervention and 30 days after intervention. Method of measurement: Fatigue Severity Scale (FSS).;Quality of Sleep. Timepoint: before intervention and 30 days after intervention. Method of measurement: Pittsburgh Sleep Quality Index. | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF Alpha Serum Level. Timepoint: before intervention and 30 days after intervention. Method of measurement: Elisa 96-test kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Abbasinazari
Shahid Beheshti University of Medical Sciences
Outcome results
None listed