Gastroesophageal reflux Disease. Gastro-esophageal reflux disease without esophagitis
Conditions
Interventions
Intervention 1: Intervention group: Sublingual administration of 3 miligram of melatonin daily for 4 weeks along with the omeprazole 20 mg daily. Intervention 2: Control group: Sublingual administrati
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients above 18 years old with compliant of heartburn, pain in behind of sternum in two or more days of week and FFSG score above or equal 8 Obtaining consent form for entry the study
Exclusion criteria
Exclusion criteria: Patients with diagnosis of gastric or duodenal ulcer Pregnant or breastfeeding women Person who consume recently antacid medications Person who under treatment of relaxing agents of gastroesophageal sphincter Liver diseases (Child C) Kidney injury (AKIN classification stage 3)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of Frequency Scale for the Symptoms of GERD (FSSG score). Timepoint: Before intervention and 4 weeks after initiation of daily use of melatonin. Method of measurement: Frequency Scale for the Symptoms of GERD questionairre (FSSG questionairre). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Abbasinazari
Shahid Beheshti University of Medical Sciences
Outcome results
None listed