Methamphetamine dependency. Dependence syndrome, other stimulants
Conditions
Interventions
Intervention 1: Transcranial Direct Current Stimulation (tDCS) is used to apply low level of electerical current to targeted brain regions from skull surface.
Electrical current applies 2mA during
During SS a ramp up and down current is applied for just 20 second in the beginning and terminating of stimulation interval and the subject will not receive any current during the interval. But the ra
In a active RALCS, subjects will receive 20 minutes 2 mA direct current by anodal (positive) electrode on the right Dorso Lateral Preferontal Cortex (DLPFC) and cathode (negative) electrode on the con
In a active RCLAS, subjects will receive 20 minutes 2 mA direct current by cathode (negative) electrode on the right Dorso Lateral Preferontal Cortex (DLPFC) and anodal (positive) electrode on the con
Transcranial Direct Current Stimulation (tDCS) is used to apply low level of electerical current to targeted brain regions from skull surface.
Electrical current applies 2mA during 20 minutes
Sham Stimulation (SS)
Right Anodal/ Left Cathodal Stimulation (RALCS)
Right Cathodal / Left Anodal Stimulation (RCLAS)
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Methamphetamine smoking as the main drug/route of abuse during last 12 months; Drug dependence diagnosis based on the DSM-IV-TR criteria; Any current or past serious neurologic disorder that would interfere with tDCS administration; Any history of brain surgery; Any co-morbid DSM-IV axis I psychiatric disorder except substance abuse based on psychiatric interview; Age: 18 to 50 years; Participating in introduction session and signing TUMS IRB approved consent form prepared according to the principles of the Declaration of Helsinki. Exclusion Criteria: If participants colud not tolerate the intervention produced by tDCS device.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional Brain Activities involved in methamphetamine craving. Timepoint: Pre- Post tDCS. Method of measurement: fMRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Methamphetamine Craving. Timepoint: Pre- Post tDCS. Method of measurement: Inventory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Hamed Ekhtiari
Research Center for Molecular and Cellular Imaging (RCMCI)
Outcome results
None listed