Food craving and obesity. Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group (active tDCS): The current level used for the study will not exceed 2mA. The stimulator ramps up the current over 30 seconds. In the sham setting, the current is ram
Sponsors
Cognitive Sciences & Technologies Council
Eligibility
Sex/Gender
All
Age
18 Years to 61 Years
Inclusion criteria
Inclusion criteria: 1. Age =18 and <61 years old2. Persian speaking3. BMI: 25-354. Frequent food cravings (=3times/day during last month) in the screening self-report5. Positive response to food cue-reactivity screening (= 50% craving in visual analog scale)6. Willing and capable of interacting with the informed consent process
Exclusion criteria
Exclusion criteria: 1. Unwillingness or inability to complete any of the major aspects of the study protocol, including magnetic resonance imaging (i.e., due to claustrophobia), food cue rating, or behavioral assessment.2. Comorbid severe psychiatric disorders (e.g. severe depression, bipolar, psychosis or background of suicide) Which is evaluated by a specialist.3. Active suicidal ideation with intent or plan determined by self-report or assessment by PI or study staff during the initial screening or any other phase of the study 4. Any active skin disorder that affects skin integrity of the scalp 5. Unstable medical disorder reported in subject’s medical history or by a clinician assessment6. Non-correctable vision or hearing problems7. History of brain injury or seizure 8. History of any brain stimulation 9. Any other condition the PI or study staff feel would put the subject at risk for entering the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood oxygen level dependent (BOLD) signal changes in the contrast between food and non-food images. Timepoint: Before and after of intervention. Method of measurement: BOLD signal differences with voxel-wise analysis in the regions of interests (ROIs) (Prefrontal cortex, Insula, Striatum, Thalamus and Extended Amygdala) in craving > neutral contrast in event-related design food cue exposure fMRI task.;Food Craving Self-Report. Timepoint: Before and after of intervention. Method of measurement: Subjective response to "On a scale of 0-100, How much "food craving" are you experiencing RIGHT NOW" measured on a visual analog scale (0-100). | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortical-Subcortical Connectivity in Resting State fMRI. Timepoint: Before and after of intervention. Method of measurement: Correlation between resting-state average Blood oxygen level dependent (BOLD) signal time series in subcortical ROIs and voxels within prefrontal cortex and Insula.;Cortical-Subcortical Task-based Connectivity in Cue Exposure fMRI. Timepoint: Before and after of intervention. Method of measurement: Psychophysiological Interaction (PPI) between average blood oxygen level dependent (BOLD) signal time series in subcortical ROIs and voxels within prefrontal cortex and Insula measured before and after tDCS (active and sham).;RAI )Allocation Index (RAI) in Resting State fMRI. Timepoint: Before and after of intervention. Method of measurement: The correlation among default mode network (DMN), saliency network (SN) and Executive Control Network (ECN) in resting state fMRI.;Area Under Electrode Connectivity in Resting State fMRI. Timepoint: Before and after of intervention. Method of measurement: Voxel-wise Psychophysiological Interaction (PPI) between average blood oxygen level dependent (BOLD) signal in the cortical area under the Anode electrode and whole brain in craving > neutral contrast in event-related designfood cue exposure fMRI task.;Food Craving Control Self-Report. Timepoint: Before and after of intervention. Method of measurement: Subjective response to "On a scale of 0-100, How much "control" do you feel you have over your "food craving" RIGHT NOW?".;Desire for Food Self Report. Timepoint: Before and after of intervention. Method of measurement: Response to the Food Craving Questionnaire (FCQ). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Hamed Ekhtiari
Laureate Institute for Brain Research
Outcome results
None listed