The Effect of Consumption of High calorie-Fruit Juice Fortified with Vitamin C in the Management of Propionic Acidemia

The Effect of Consumption of High calorie-Fruit Juice Fortified with Vitamin C on Protein Intake, Oxidative Stress and Amino Acid Profile of Children with Propionic Acidemia.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20121019011168N3

Enrollment

Registered

2018-08-19

Start date

2018-08-01

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Propionic acidaemia. Other disorders of branched-chain amino-acid metabolism_Propionic acidaemia

Interventions

Intervention 1: Consumption of natural high calorie-fruit Juice fortified with vitamin C for 12 weeks

Intervention group. Intervention 2: Consumption of natural fruit Juice for 12 weeks

Control group.

Eligibility

Sex/Gender

All

Age

2 Years to 6 Years

Inclusion criteria

Inclusion criteria: Children 2-6 years of age Suffering from propionic acidemia (PA) according to metabolic panel test Confirmation of the disease by genetic test (if possible) Parental consent for participation in the study and daily intake of fruit juice Monthly cycles of one-week metronidazole therapy (10-20 mg/kg).

Exclusion criteria

Exclusion criteria: Parental dissent for participation in the study and daily intake of fruit juice

Design outcomes

Primary

Measure	Time frame
Amino acid profile. Timepoint: Before intervention, after intervention. Method of measurement: HPLC method.;Ammonia. Timepoint: Before intervention, after intervention. Method of measurement: Spectrophotometry.	—

Secondary

Measure	Time frame
Serum vitamin C. Timepoint: Before intervention, after intervention. Method of measurement: HPLC method.;Serum glutathione peroxidase. Timepoint: Before intervention, after intervention. Method of measurement: Enzymatic, colorimetric method.;Serum superoxide dismutase. Timepoint: Before intervention, after intervention. Method of measurement: Enzymatic, colorimetric method.;Total antioxidant capacity. Timepoint: Before intervention, after intervention. Method of measurement: Enzymatic, colorimetric method.;Serum total protein. Timepoint: Before intervention, after intervention. Method of measurement: Autoanalyzer, colorimetric method.;Serum Albumin. Timepoint: Before intervention, after intervention. Method of measurement: Autoanalyzer, colorimetric method.;Serum Prealbumin. Timepoint: Before intervention, after intervention. Method of measurement: Immunoturbidimetric method.	—

Measure

Time frame

Serum vitamin C. Timepoint: Before intervention, after intervention. Method of measurement: HPLC method.;Serum glutathione peroxidase. Timepoint: Before intervention, after intervention. Method of measurement: Enzymatic, colorimetric method.;Serum superoxide dismutase. Timepoint: Before intervention, after intervention. Method of measurement: Enzymatic, colorimetric method.;Total antioxidant capacity. Timepoint: Before intervention, after intervention. Method of measurement: Enzymatic, colorimetric method.;Serum total protein. Timepoint: Before intervention, after intervention. Method of measurement: Autoanalyzer, colorimetric method.;Serum Albumin. Timepoint: Before intervention, after intervention. Method of measurement: Autoanalyzer, colorimetric method.;Serum Prealbumin. Timepoint: Before intervention, after intervention. Method of measurement: Immunoturbidimetric method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyedeh Maryam Abdolahzadeh

Shiraz University of Medical Sciences

abdolahsm@sums.ac.ir+98 71 3725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026