Condition 1: conduction disorder. Condition 2: General anesthesia. Other specified conduction disorders Cardiac arrest, unspecified
Conditions
Interventions
Intervention 1: In one group , as anesthetic premedication , bolus dose of intravenous remifentanil (2 µg / kg over 60 seconds) will be given followed by its infusion ( 0.15 µg / kg / min ) throught
Prevention
In one group , as anesthetic premedication , bolus dose of intravenous remifentanil (2 µg / kg over 60 seconds) will be given followed by its infusion ( 0.15 µg / kg / min ) throught maintenance of
In the other group , as anesthetic premedication , bolus dose of alfentanil ( 20 µg / kg over 60 seconds ) will be followed by its infusion ( 0.25 µg / kg / min )throught maintenance of anesthesia
Sponsors
Shiraz university of medical sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age between 18-35 years; ASA - PS ( American Society of Anesthesiologist- Physical Status) : I ; Elective ENT ( Ear-Nose-Throat ) operation under general anesthesia. Exclusion criteria : Abnormal serum electrolytes, cardiovascular or psychiatric problems; idiopathic or acquired prolonged QT interval;anticipated difficulty in tracheal intubation ; patients taking any medication affecting QTc interval ( e.g. :tricylic antidepressant ,antidysrhythmics, ß-adrenergic antagonists, calcium channel blockers); existence of cardiac valvular disease; any cardiac rhythm abnormality; diabetes mellitus ; pregnancy ; obesity ( body mass index > 30 ) and hypersensitivity reaction to egg, fish or soya bean .
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QT interval. Timepoint: Before and 90 seconds after induction of anesthesia, 1 and 5 minutes after endotracheal intubation. Method of measurement: Electrocardiograph. | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate. Timepoint: Before and 90 seconds after induction of anesthesia, 1 and 5 minutes after endotracheal intubation. Method of measurement: Operating room monitor.;Blood pressure. Timepoint: Before and 90 seconds after induction of anesthesia, 1 and 5 minutes after endotracheal intubation. Method of measurement: Operating room monitor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMansoor Masjedi,
Shiraz Anesthesiology and Critical Care Research Center, Department Of Anesthesia, Medical school ,
Outcome results
None listed