Diabetic neuropathy. Autonomic neuropathy in endocrine and metabolic diseases
Conditions
Interventions
Intervention 1: Intervention : Tablet Topiramate 50 mg ,twice daily ,duration 3 month. Intervention 2: Control : Tablet Amitriptyline 25 mg , twice daily , for 3 month.
Treatment - Drugs
Intervention : Tablet Topiramate 50 mg ,twice daily ,duration 3 month
Control : Tablet Amitriptyline 25 mg , twice daily , for 3 month
Sponsors
Endocrine Research Centre of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria :patients with diabetes mellitus ; both genders ; between 18-80 years of age ; under anti hyperglycemic agents therapy ;with diabetic peripheral neuropathy syptoms in the form of pain and paresthesia in rest for at least 1 month. Exclusion criteria : persons with any important clinical disease; unstable clinical or psychologic disease ; other neurupathic causes ;renal dysfunction ;liver disease ; epilepsy ;psychiatric disease ;uncontroled HTN ;malignancy ;opiate addiction ;anti epileptic ,anti depressant , topical anti pain or opioid tretmant ;pregnant and lactating women ; need to change treatment.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment. Timepoint: 3 month. Method of measurement: History and Physical Exam , EMG/NCV if needed. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Hasan Fazlazar Sharabiani
Endocrine Research Centre
Outcome results
None listed