comparison of three drugs to prevent hemodynamic response of orothracheal intubation

Comparison Effect of Fentanyl, Sufentanil and Alfentanil on Hemodynamic at Rapid Sequence Intubation in the Emergency Department

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012101011067N1

Enrollment

Registered

2013-05-12

Start date

2012-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

accidents. Accidents

Interventions

Intervention 1: Intervention group 1: 30 accidental patients with normal blood pressure that will require intubation with rapid sequence method, alfentanil, single dose intravenous administration 20 m

Treatment - Drugs

Intervention group 1: 30 accidental patients with normal blood pressure that will require intubation with rapid sequence method, alfentanil, single dose intravenous administration 20 micrograms per ki

Intervention group 1: 30 accidental patients with normal blood pressure that will require intubation with rapid sequence method, sufentanil, single dose intravenous administration 0.2 micrograms per k

Control group: 30 accidental patients with normal blood pressure that will require intubation with rapid sequence method, fentanyl, single dose intravenous administration 2 micrograms per kilogram (1

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria include all traumatic patients with normal blood pressure that require intubation in the Emergency Department of Imam Reza (AS) Medical Research and Training Hospital. Exclusion criteria:Crush intubation, Asthma, Chronic Obstructive Pulmonary Disease, Porphyry, Allergy to lidocaine,difficult intubation based on physician's clinical judgment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: SAADAT Monitoring Device (Model Number: Novin S1800, Pooyandegan Rah Saadat Incorporation, Tehran, Iran).;Blood Pressure. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: SAADAT Monitoring Device (Model Number: Novin S1800, Pooyandegan Rah Saadat Incorporation, Tehran, Iran.;Cardiac Output. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: NICO Monitoring Device (Model Number:7300, Novametrix Incorporation, Wallingford, United States of America).;Pressure of End Tidal Carbon Dioxide. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: NICO Monitoring Device (Model Number:7300, Novametrix Incorporation, Wallingford, United States of America.;Arterial Oxygen Saturation. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: SAADAT Monitoring Device (Model Number: Novin S1800, Pooyandegan Rah Saadat Corporation, Tehran, Iran).	—

Measure

Time frame

Heart Rate. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: SAADAT Monitoring Device (Model Number: Novin S1800, Pooyandegan Rah Saadat Incorporation, Tehran, Iran).;Blood Pressure. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: SAADAT Monitoring Device (Model Number: Novin S1800, Pooyandegan Rah Saadat Incorporation, Tehran, Iran.;Cardiac Output. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: NICO Monitoring Device (Model Number:7300, Novametrix Incorporation, Wallingford, United States of America).;Pressure of End Tidal Carbon Dioxide. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: NICO Monitoring Device (Model Number:7300, Novametrix Incorporation, Wallingford, United States of America.;Arterial Oxygen Saturation. Timepoint: 5 minute before intubation, 3 minute after intubation, 5 minute after intubation, 10 minute after intubation and. Method of measurement: SAADAT Monitoring Device (Model Number: Novin S1800, Pooyandegan Rah Saadat Corporation, Tehran, Iran).

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Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026