Effect of different methods of remifentanil administration in labor pain

Comparison of Incremental Bolus and Infusion Administration of Remifentanil on Labor Pain and Length of Delivery Time in Women During Labor.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012100811020N2

Enrollment

Registered

2013-02-18

Start date

2012-01-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Single spontaneous delivery. cases with minimal or no assistance, with or without episiotomy

Interventions

Intervention 1: If the intensity of pain reaches to 7 or more (based on verbal numeric grading criteria) in group A, remifentanil (in method of incremental infusion) will be prescribed from 0.025 micr

Treatment - Drugs

If the intensity of pain reaches to 7 or more (based on verbal numeric grading criteria) in group A, remifentanil (in method of incremental infusion) will be prescribed from 0.025 microgram per kg of

If the intensity of pain reaches to 7 or more (based on verbal numeric grading criteria) in group B, remifentanil (in method of incremental bolus) will be prescribed in dose of 0.25 microgram per kg,

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: primigravid healthy parturient with 37-42 weeks of pregnancy; in active stage of labor (uterine contraction 3 per 10 minutes, lasting for 30 to 40 seconds and cervical dilation >=3 cm); with vertex presentation. Exclusion criteria: parturient with positive history of preeclampsia; using psychiatric drugs; using opioid and alcohol; antenatal hemorrhage; fetal distress; BMI>30 or <20; multi tone and requesting for epidural analgesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of uterine contractions pain. Timepoint: Every 15 minutes from the onset of active phase of labor to delivery. Method of measurement: verbal numeric rating scale (VNRS).;First stage of labour duration. Timepoint: every 15 minutes in first stage of labour from 4 cm dilation up to 10 cm, and in second stage from 10 cm dilation up to delivery. Method of measurement: Time by minutes.	—

Secondary

Measure	Time frame
Grading of sedation. Timepoint: every 15 minutes. Method of measurement: Modified Observer's Assessment of Alertness.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Khooshide

Tehran University of Medical Sciences

khooshide@tums.ac.ir+98 21 7788 3288

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026